Table 4. Univariate and multivariate analyses for the association between the DFS and the clinicopathological factors.
| Factors | N | Univariate analysis | Multivariate analysis | |||||
|---|---|---|---|---|---|---|---|---|
| HR | 95% CI | P value | HR | 95% CI | P value | |||
| Age (years) | ||||||||
| <70 | 47 | 1.000 | 1.000 | |||||
| ≥70 | 61 | 1.613 | 0.913–2.919 | 0.100 | 2.286 | 1.246–4.304 | 0.007 | |
| Sex | ||||||||
| Female | 12 | 1.000 | ||||||
| Male | 96 | 1.102 | 0.507–2.889 | 0.821 | ||||
| Smoking history | ||||||||
| Never-smoker | 33 | 1.000 | ||||||
| Smoker | 75 | 1.359 | 0.746–2.621 | 0.324 | ||||
| BMI (kg/m2) | ||||||||
| ≥20 | 47 | 1.000 | ||||||
| <20 | 61 | 0.790 | 0.452–1.377 | 0.404 | ||||
| CONUT | ||||||||
| Low | 76 | 1.000 | 1.000 | |||||
| High | 32 | 2.070 | 1.147–3.638 | 0.017 | 1.902 | 1.045–3.373 | 0.036 | |
| Pathological T status | ||||||||
| 1 | 37 | 1.000 | ||||||
| ≥2 | 71 | 1.670 | 0.098–3.258 | 0.098 | ||||
| Pathological N status | ||||||||
| 0 | 79 | 1.000 | ||||||
| ≥1 | 29 | 1.698 | 0.931–2.995 | 0.083 | ||||
| Pathological stage | ||||||||
| I | 61 | 1.000 | 1.000 | |||||
| ≥II | 47 | 2.272 | 1.304–4.011 | 0.004 | 2.527 | 1.391–4.644 | 0.002 | |
| G | ||||||||
| 1 | 15 | 1.000 | ||||||
| 2, 3 | 93 | 1.185 | 0.544–3.107 | 0.691 | ||||
| PL | ||||||||
| Negative | 65 | 1.000 | ||||||
| Positive | 43 | 1.564 | 0.896–2.713 | 0.115 | ||||
| LY | ||||||||
| Negative | 92 | 1.000 | 1.000 | |||||
| Positive | 16 | 2.347 | 1.142–4.433 | 0.022 | 2.321 | 1.110–4.493 | 0.027 | |
| V | ||||||||
| Negative | 59 | 1.000 | ||||||
| Positive | 49 | 1.648 | 0.950–2.887 | 0.076 | ||||
| Surgical procedure | ||||||||
| ≥ Lobectomy | 80 | 1.000 | ||||||
| Sublobar resection | 28 | 0.948 | 0.474–1.761 | 0.871 | ||||
| Adjuvant chemotherapy | ||||||||
| None | 93 | 1.000 | ||||||
| Administered | 15 | 1.047 | 0.454–2.121 | 0.906 | ||||
CONUT, controlling nutrition status; PL, pleural invasion; LY, lymphatic invasion; V, vascular invasion.