Table S5. Pulmonary function tests of patients.
| Variables | Cluster 1 | Cluster 2 | Cluster 3 | Cluster 4 | Total | P |
|---|---|---|---|---|---|---|
| FVC% pred | 81.5 (16.2) | 83.6 (14.7) | 80.9 (18.6) | 62.5 (14.3) | 78.9 (17.6) | <0.001 |
| FEV1% pred | 68.6 (17.9) | 65.6 (17.0) | 71.6 (19.8) | 39.2 (14.3) | 63.5 (20.7) | <0.001 |
| FEV1/FVC | 71.3 (12.0) | 63.5 (11.0) | 73.0 (9.4) | 50.3 (13.6) | 65.7 (13.8) | <0.001 |
| MMEF% pred | 44.8 (22.5) | 39 (18.5) | 45.3 (26.0) | 18.6 (16.1) | 38.8 (23.1) | <0.001 |
| MEF25%% pred | 40.4 (25.5–58.3) | 32.8 (23.4–48.7) | 43.8 (28.4–59.9) | 16.5 (13.4–24.7) | 34.2 (22.9–50.6) | <0.001 |
| MEF50%% pred | 44.6 (22.3) | 39.1 (19.7) | 44.1 (25.0) | 17.9 (17.2) | 38.3 (23.3) | <0.001 |
| MEF75%% pred | 51.5 (21.4) | 44.4 (21.2) | 53.3 (22.2) | 20.6 (16.9) | 44.5 (23.6) | <0.001 |
| RV/TLC | 44.2 (10.7) | 45.2 (9.9) | 49.3 (10.0) | 55.2 (10.0) | 47.7 (10.8) | <0.001 |
| R4-R24 | 0.49 (0.24–1.03) | 0.74 (0.36–1.21) | 0.78 (0.25–1.29) | 1.39 (0.65–1.93) | 0.76 (0.33–1.36) | <0.05 |
| FeNO | 24.2 (14.2–43.1) | 26 (15–67.2) | 18.3 (14–57.1) | 24 (9.6–41) | 23.5 (14–50.7) | 0.545 |
| Post FEV1% pred | 73.8 (17.9) | 74.8 (19.0) | 79.4 (20.2) | 44.0 (14.9) | 70.6 (22.0) | <0.001 |
| Post FVC% pred | 86.0 (16.1) | 90.0 (15.8) | 87.3 (18.4) | 69.7 (14.6) | 84.9 (17.7) | <0.001 |
| Post FEV1/FVC | 72.6 (12.7) | 65.6 (13.8) | 75.4 (8.8) | 48.8 (16.0) | 67.1(15.6) | <0.001 |
| Change in FEV1 (L) | 0.12 (0.04–0.27) | 0.26 (0.08–0.41) | 0.13 (0.04–0.25) | 0.13 (0.05–0.21) | 0.16 (0.06–0.29) | <0.05 |
Data are presented as the mean (SD) or median (IOR). P value from one-way ANOVA and nonparametric test (Kruskal-Wallis) among the four clusters. FVC% pred, forced vital capacity% predicted; FEV1% pred, forced expiratory volume in the first second% predicted; FEV1/FVC, ratio of forced expiratory volume in the first second to forced vital capacity; RV, residual volume; TLC, total lung capacity; MMEF% pred, maximal mid-expiratory flow% predicted; MEF25%, maximal expiratory flow in 25% vital capacity; MEF50%, maximal expiratory flow in 50% vital capacity; MEF75%, maximal expiratory flow in 75% vital capacity; FeNO, fraction of expired nitric oxide.