Fig. 30. (a) Multicomponent Povarov coupling reaction of benzaldehyde, aniline, and dihydropyrane (DHP) leading to pyranoquinolines; (b) the zirconium-MOF acts as a “macroligand” favoring the exo addition of DHP to the coordinated imine, which results in the diastereoselective formation of the trans isomer.