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. Author manuscript; available in PMC: 2017 Nov 30.
Published in final edited form as: Cell Rep. 2017 Oct 31;21(5):1180–1190. doi: 10.1016/j.celrep.2017.10.016

Figure 4.

Figure 4

Comparison of viral replication and innate cytokine responses in mouse DCs. Bone marrow-derived DCs from A129 mice were infected with WT or E N154Q mutant virus at an MOI of 1. At days 1, 3, and 4 p.i., extracellular infectious viruses (A) and intracellular viral RNAs (B) were measured by plaque assay and quantitative RT-PCR, respectively. In addition, quantitative RT-PCR was used to quantify intracellular mRNA levels of different cytokines, including IFNα, IFNβ, IL-1β, IL-6, IL-12p40, and TNFα (C). Data are presented as means ± SEM, n = 6. Statistical significance is presented as P < 0.05 (*), P< 0.01 (**), and P < 0.001 (***) when compared to the WT ZIKV-infected group using unpaired t test.