Table 1. Functions ranked based on functional variability of genes.
Top 10 gained (green) and lost (red) functions are shown, along with Δf, Δf divided (normalized) by the number of genes annotated by the function, followed by the sample shuffling, and the log fold change, which is the log ratio of the average number of expressed genes annotated by f in cancer and normal samples.
| GO ID | Description | Δf | Normalized Δf | Δf (After Sample shuffling) | Normalized Δf (After Sample Shuffling) | log fold change |
|---|---|---|---|---|---|---|
| GO:0048661 | positive regulation of smooth muscle cell proliferation | 893 | 15.13 | 11 | 0.18 | -0.04 |
| GO:0048010 | vascular endothelial growth factor receptor signaling pathway | 744 | 10.19 | -28 | -0.38 | -0.01 |
| GO:0051279 | regulation of release of sequestered calcium ion into cytosol | 740 | 13.21 | 0 | 0 | -0.03 |
| GO:1901983 | regulation of protein acetylation | 723 | 12.05 | -10 | -0.16 | -0.04 |
| GO:0000910 | cytokinesis | 527 | 6.84 | -8 | -0.10 | -0.02 |
| GO:0010676 | positive regulation of cellular carbohydrate metabolic process | 523 | 8.43 | -22 | -0.35 | -0.05 |
| GO:0051291 | protein hetero oligomerization | 508 | 5.90 | 12 | 0.13 | -0.03 |
| GO:0042552 | myelination | 394 | 6.67 | -6 | -0.10 | -0.03 |
| GO:2000756 | regulation of peptidyl-lysine acetylation | 369 | 6.47 | -10 | -0.17 | -0.03 |
| GO:0016575 | histone deacetylation | 333 | 5.64 | -17 | -0.28 | -0.01 |
| GO:0006334 | nucleosome assembly | -310 | -3.13 | -3 | -0.03 | 0.04 |
| GO:0051148 | negative regulation of muscle cell differentiation | -127 | -2.49 | -15 | -0.29 | -0.06 |
| GO:0007032 | endosome organization | -75 | -1.27 | -2 | -0.03 | -0.007 |
| GO:0018022 | peptidyl-lysine methylation | -65 | -0.91 | -10 | -0.14 | 0.002 |
| GO:0007052 | mitotic spindle organization | -64 | -1.05 | -15 | -0.24 | 0.005 |
| GO:0019886 | antigen processing and presentation of exogenous peptide antigen via MHC class II | -56 | -0.62 | 2 | 0.02 | 0.003 |
| GO:0016236 | macroautophagy | -53 | -0.71 | -13 | -0.17 | -0.01 |
| GO:2000117 | negative regulation of cysteine-type endopeptidase activity | -52 | -0.61 | -4 | -0.04 | 0.005 |
| GO:0051437 | pos reg of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition | -51 | -0.68 | 3 | 0.04 | 0.006 |
| GO:0031145 | anaphase-promoting complex-dependent catabolic process | -43 | -0.57 | 7 | 0.09 | 0.006 |