Table 3. Links between functional loss and mutation and deletion CNV.

The Fisher test contingency table showing the distribution of functions with elevated missense mutation frequency (columns 2 and 3) and deletion CNV rates (columns 4 and 5) between lost and gained functions. Mut(f) = 1 denotes significantly higher missense mutation frequency among the genes contributing to functional gain. CNV(f) = 1 has an analogous interpretation for deletion CNV.

	Mut(f) = 1	Mut(f) = 0	CNV(f) = 1	CNV(f) = 0
Δf < 0	23	709	26	706
Δf > 0	27	390	7	410