Fig 5. Gene expression analysis for molecules associated with tissue remodeling and endothelial cell functions in pericystic brain tissues with EB extravasation, from infected pigs following PZQ treatment with or without pretreatment with anti-inflammatory agents.

Expression of MMP1 (A), MMP9 (B), TIMP1 (C), TIMP2 (D), VEGF (E), PECAM1 (F), angiopoietin 1 (Ang1; G) and angiopoietin 2 (Ang2; H) are shown as fold expression as detailed in the legend for Fig 3. Each dot represents an individual capsule; bars represent the mean and error bars are the standard deviations. Within each study group, different numbers of cysts were analyzed for each of the markers shown. Group labels are the same as for Fig 2 and asterisks indicate level of significance as listed in Fig 2.