Table 2. Positive Goldstream Fungus (1–3)-β-D-glucan assays in patients with a P. jirovecii infection, invasive aspergillosis, mucormycosis, and TB, as well as healthy volunteers.
| PCP (n = 50) |
Candidemia (n = 15) |
CDC (n = 6) |
Aspergillosis (n = 15) |
Mucormycosis (n = 10) |
TB (n = 20) |
Healthy controls (n = 20) |
|
|---|---|---|---|---|---|---|---|
| BG>31.25a | 46 (92%,95% CI 82–98) |
13 (87%,95% CI 60–98) |
4 (67%,95% CI 22–96) |
9 (60%,95% CI32-84) |
6 (60%,95% CI 26–88) |
10 (50%,95% CI 27–73) |
8 (40%,95% CI 19–64) |
| BG>60b | 43 (86%,95% CI 73–94) |
13 (87%,95% CI 60–98) |
3 (50%,95% CI 12–88) |
6 (40%,95% CI 16–68) |
3 (30%,95% CI 7–65) |
7 (35%,95% CI 15–59) |
6 (30%,95% CI 12–54) |
| BG>80c | 37 (74%,95% CI 60–85) |
12 (80%,95% CI 52–96) |
2 (33%,95% CI 4–78) |
6 (40%,95% CI 16–68) |
2 (20%,95% CI 3–56) |
5 (25%,95% CI 9–49) |
5 (25%, 95% CI 9–49) |
| BG>64.21d | 43 (86%,95% CI 73–94) |
13 (87%,95% CI 60–98) |
3 (50%,95% CI 12–88) |
6 (40%,95% CI 16–68) |
3 (30%,95% CI 7–65) |
6 (30%,95% CI 12–54) |
6 (30%,95% CI 12–54) |
Abbreviations: PCP, Pneumocystis pneumonia; CDC, chronic disseminated candidiasis; TB, TB; CI, confidence interval; BG, (1–3)-β-D-glucan.
Data are no. (%) patients unless otherwise indicated.
a Optimal cut-off value with high sensitivity at the expense of specificity for PCP versus TB plus healthy control
b Manufacturer-recommended cut-off point for the negative value of (1–3)-β-D-glucan assay
c Manufacturer-recommended cut-off point for the positive value of (1–3)-β-D-glucan assay
d Optimal cut-off value as the point of the ROC curve farthest from the diagonal line for PCP versus TB plus healthy control