Table 3. Diagnostic performance of the Goldstream Fungus (1–3)-β-D-glucan test in Pneumocystis jirovecii vs. TB plus healthy volunteers.
| Sensitivity % (n/N,a 95% CI) |
Specificity % (n/N,b 95% CI) |
PPV (95% CI) |
NPV (95% CI) |
Positive likelihood ratio (95% CI) |
Negative likelihood ratio (95% CI) |
|
|---|---|---|---|---|---|---|
| BG>31.25c | 92 (46/50, 81–98) |
55 (22/40, 38–71) |
72 (59–82) |
85 (65–96) |
2.04 (1.44–2.91) |
6.88 (2.58–18.33) |
| BG>60d | 86 (43/50, 73–94) |
68 (27/40, 51–81) |
77 (64–87) |
79 (62–91) |
2.65 (1.67–4.19) |
4.82 (2.35–9.90) |
| BG>64.21e | 84 (42/50, 71–93) |
70 (28/40, 53–83) |
78 (64–88) |
78 (61–90) |
2.8 (1.72–4.56) |
4.38 (2.25–8.52) |
| BG>80f | 74 (37/50, 60–85) |
75 (30/40, 59–87) |
79 (64–89) |
70 (54–83) |
2.96 (1.69–5.19) |
2.88 (1.75–4.76) |
Abbreviations: PCP, Pneumocystis pneumonia; TB, TB, CI, confidence interval; BG, (1–3)-β-D-glucan.
Data are no. (%) patients unless otherwise indicated.
a Sensitivity was determined by dividing the no of patients with a positive test results by the number of patients with PCP tested
b Specificity was determined by dividing the no of patients with a negative test results by the number of healthy control tested
c Optimal cut-off value with high sensitivity at the expense of specificity for PCP versus TB plus healthy control
d Manufacturer-recommended cut-off point for the negative value of the (1–3)-β-D-glucan
e Optimal cut-off value as the point of the ROC curve farthest from the diagonal line for PCP versus TB plus healthy control
f Manufacturer-recommended cut-off point for the positive value of the (1–3)-β-D-glucan