Table 1. Demographics.

	Dose Level 1	Dose Level 2	Dose Level 3	Dose Level 4	Total
	6.75 μg	22.5 μg	67.5 μg	225 μg
	(0.3 μM)	(1 μM)	(3 μM)	(10 μM)
	N = 3 (100%)	N = 3 (100%)	N = 3 (100%)	N = 3 (100%)	N = 12 (100%)
Age (years)
Mean	65.0	63.0	66.7	70.0	66.2
Median	68.0	64.0	64.0	68.0	67.0
SD	± 13.75	± 16.52	± 4.62	± 5.29	± 10.01
Range	50–77	46–79	64–72	66–76	46–79
Gender
male, number (%)	1 (33.3)	2 (66.7)	2 (66.7)	2 (66.7)	7 (58.3)
female, number (%)	2 (66.7)	1 (33.3)	1 (33.3)	1 (33.3)	5 (41.7)
Type of POAG
high tension POAG	3 (100.0)	2 (66.6)	2 (66.6)	2 (66.6)	9 (75.0)
normal tension POAG	0 (0.0)	1 (33.3)	1 (33.3)	1 (33.3)	3 (25.0)
Involved eye
OD	0 (0.0)	0 (0.0)	0 (0.0)	0 (0.0)	0 (0.0)
OS	2 (66.7)	0 (0.0)	0 (0.0)	0 (0.0)	2 (16.7)
OU	1 (33.3)	3 (100.0)	3 (100.0)	3 (100.0)	10 (83.3)
Time since diagnosis of POAG (years)
Mean	20.0	9.3	16.3	3.3	12.3
Median	23.0	10.0	10.0	3.0	8.5
SD	±15.72	± 15.72	± 13.65	± 1.53	± 11.18
Range	3–34	7–11	7–32	2–5	2–34
IOP (mmHG) prior to trabeculectomy
Mean	36.3	23.3	20.5	28.83	27.25
Median	27.0	23.0	23.0	26.0	23.8
SD	± 18.82	± 9.5	± 4.77	± 13.48	± 12.56