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. 2017 Nov 30;12(11):e0188303. doi: 10.1371/journal.pone.0188303

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© 2017 Broquetas et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 1 — A and B. Different kinetics of qHBsAg in HBeAg-negative CHB patients receiving NAs. Fig 1A shows the kinetics of qHBsAg (log IU/mL) in patients who did not achieve low levels (>120 IU/mL) during follow-up (n = 82). Fig 1B shows the kinetics of qHBsAg in patients who achieved low levels (<120 IU/mL) during follow-up (n = 10). Using a mathematical mixed model for repeated measurements, the slope in patients who achieved low levels of HBsAg (y = 3.22–0.257x(t)) was significantly greater compared to those who did not (y = 3.66–0.057x(t)) (p <0.001).