TABLE 1.
Fibrosis Stage ≥1 | Fibrosis Stage ≥2 | Fibrosis Stage ≥3 | Fibrosis Stage 4 | ||||||||||
Technique | Study | Sensitivity | Specificity | AUC | Sensitivity | Specificity | AUC | Sensitivity | Specificity | AUC | Sensitivity | Specificity | AUC |
Magnetic resonance elastography | Wang et al, 201227 | 0.83 | 0.99 | 0.95 | 0.94 | 0.95 | 0.98 | 0.92 | 0.96 | 0.98 | 0.99 | 0.94 | 0.99 |
Singh et al, 201528 | 0.73 | 0.79 | 0.84 | 0.79 | 0.81 | 0.88 | 0.85 | 0.85 | 0.93 | 0.91 | 0.81 | 0.92 | |
Guo et al, 201529 | 0.87 | 0.93 | 0.94 | 0.87 | 0.94 | 0.97 | 0.87 | 0.92 | 0.96 | 0.93 | 0.91 | 0.97 | |
Diffusion-weighted imaging | Wang et al, 201227 | 0.81 | 0.82 | 0.86 | 0.77 | 0.78 | 0.83 | 0.72 | 0.84 | 0.86 | — | — | — |
Jiang et al, 201630 | 0.78 | 0.78 | 0.86 | 0.81 | 0.8 | 0.88 | 0.71 | 0.84 | 0.88 | 0.8 | 0.77 | 0.86 | |
Texture | |||||||||||||
Unenhanced | House et al, 201531 | — | — | 0.78–0.87 | — | — | — | — | — | — | — | — | — |
Kato et al, 200732 | — | — | 0.53–0.60 | — | — | — | — | — | — | — | — | — | |
Double enhanced | Aguirre et al, 200633 | — | — | — | — | — | — | — | — | 0.82–0.89 | — | — | — |
Bahl et al, 201234 | — | — | — | — | — | — | 0.919 | 0.839 | — | — | — | — | |
Yokoo et al, 201535 | 0.659 | 0.8 | 0.814 | 0.895 | 0.778 | 0.889 | 0.778 | 0.784 | 0.862 | 1 | 0.93 | 0.976 | |
Gd enhanced | Kato et al, 200732 | — | — | 0.62–0.80 | — | — | — | — | — | — | — | — | — |
Superparamagnetic iron oxide enhanced | Aguirre et al, 200633 | — | — | — | — | — | — | — | — | 0.40–0.84 | — | — | — |
Perfusion imaging | Hagiwara et al, 200836 | — | — | — | — | — | — | 0.31–0.92 | 0.64–1.00 | 0.61–0.82 | — | — | — |
Ou et al, 201337 | 0.78 | 0.84 | 0.83 | 0.90 | 0.77 | 0.85 | 0.81 | 0.85 | 0.88 | 0.80 | 0.89 | 0.92 | |
Patel et al, 201038 | — | — | — | — | — | — | — | — | — | 0.50–1.00 | 0.50–1.00 | 0.57–0.95 | |
Hepatocellular function imaging | Choi et al, 201339 | 0.46 | 0.85 | — | 0.46 | 0.82 | — | 0.63 | 0.68 | — | 0.76 | 0.65 | — |
Feier et al, 201340 | 0.70 | 0.85 | 0.81 | 0.75 | 0.77 | 0.82 | 0.73 | 0.87 | 0.85 | 0.83 | 0.80 | 0.83 | |
Goshima et al, 201241 | 1.00 | 0.73 | 0.91 | 1.00 | 0.87 | 0.96 | 0.74 | 0.98 | 0.93 | 0.91 | 1.00 | 0.97 | |
Motosugi et al, 201142 | 0.87 | 0.75 | 0.82 | 0.75 | 0.56 | 0.68 | 0.75 | 0.50 | 0.63 | 0.82 | 0.49 | 0.62 | |
T1ρ | Allkemper et al, 201443 | — | — | — | — | — | — | — | — | — | 1.00 | 0.84 | 0.97 |
Adapted from Petitclerc et al.44.
AUC indicates area under the receiver operating characteristic curve.