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FH19 (residues 1104–1164) from FH19-20 structure (PBD 2G71, pink [18] is aligned to chain F (deep blue), the published complex structures with OspE (4J38, yellow) [30] and with C3d (2XQW, grey) [23]. The orientation of FH20 residues 1201–1515 in the important target recognition loop is clearly different.
