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(A) DHCA interacted with HDAC1 by forming three hydrogen bonds with I79, F103 and G105 amino acid residues (B) The key amino acids residues of HDAC2 such as H145, H146, G154 and Y308 were involved in hydrogen bonding with DHCA (C) While interaction between HDAC3, and DHCA was by formation of hydrogen bond with—R301 (D) The amino acids D101, H180 and Y306 of HDAC8 interacted with DHCA. (E) DHCA also interacted with class II HDAC-4 by forming bonds with ARG154, LYS20 and HIS21.
