Figure 2.

Classification of VWD patients based on central phenotypic diagnosis and final assignment according to the genotype-phenotype correlation. The dataset highlights the number of patients reincluded or reclassified after molecular study, from the initial classification based on central phenotypic results (shown in black) to a definite, refined classification based on molecular data analysis together with phenotypic results (shown in gray). *Patients diagnosed initially as type 1 VWD and reclassified to type 2M VWD due to the presence of collagen binding mutations.^† Patient with uncertain classification reclassified to type 3 VWD due to the presence of nonsense mutation in homozygous state. This is a discrepant case since laboratory levels do not correlate and it is pending a new analysis from a freshly obtained sample. Out: number of patients removed from this subtype; To: final definite classification; In: number of patients reclassified to this subtype; From: previous phenotypic classification; UC: uncertain classification; AVWS: acquired von Willebrand Syndrome.