Figure 3.

Summary of the final diagnosis of patients in terms VWD type. On the basis of phenotype data, 98 of the 556 recruited individuals did not meet any inclusion criteria and were initially excluded. Following the molecular analysis, 43 of these patients were reincluded due to the presence of a candidate mutation in VWF. The remaining 55 patients did not meet any inclusion criteria. Moreover, molecular analysis prompted the exclusion of 21 additional individuals: eight HA patients, five HA carriers, and eight patients finally diagnosed as AVWS and confirmed by the absence of mutations in VWF or GP1BA. Of note, 280 families were finally included (shown in black) and nine of them had members with different VWD types. In those particular cases, the family may be counted more than once; that is, within each VWD type where a family member was classified. VWD: von Willebrand disease.