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. Author manuscript; available in PMC: 2018 Sep 1.
Published in final edited form as: Psychopharmacology (Berl). 2017 May 31;234(17):2597–2605. doi: 10.1007/s00213-017-4652-3

Figure 4.

Figure 4

Effects of a thermal antinociceptive dose of oxycodone, nalfurafine, and three mixtures on pulmonary ventilation (Experiment 4). Mean ±SEM percent change in pulmonary ventilation following treatment with a thermal antinociceptive dose (ED80 value from Experiment 3) of the drug mixtures. Doses (oxycodone+nalfurafine) are as follows (mg/kg): oxycodone: 5.9+0; nalfurafine: 0+0.317; 175:1: 2.74+0.015; 56:1: 2.5+0.044; 18:1: 0.73+0.041. Filled bars indicate a significant difference between saline and a drug condition (p<0.05).