Table 3.

Mean Relative Proportion (Standard Deviation) and Adjusted P Values for PDAC vs Controls and PDAC vs IPMNs for 17 Taxa with Significant Differences (p<0.05) between PDAC and Controls.

	PDAC vs Controls			PDAC vs IPMN
Taxa	PDAC (n=40)	Controls (n=58)	P value	IPMN (n=39)	P value
	Mean (SD)	Mean (SD)		Mean (SD)
Phyla
Firmicutes	.55 (.16)	.44† (.11)	0.0002	.45† (.11)	0.0003
Proteobacteria	.13 (.12)	.24† (.14)	0.0001	.19† (.14)	0.01
Class
Bacilli	.30 (.20)	.21† (.10)	0.02	.21 (.09)	0.007
Gammaproteobacteria	.07 (.08)	.14† (.08)	0.0004	.10† (.08)	0.03
Betaproteobacteria	.05 (.06)	.10† (.08)	0.002	.09† (.09)	0.04
Order
Lactobacillales	.26 (.18)	.18† (.10)	0.02	.19 (.09)	0.006
Pasteurellales	.07 (.08)	.14† (.08)	0.0004	.10† (.08)	0.03
Neisseriales	.05 (.06)	.10† (.08)	0.001	.09† (.09)	0.03
Family
Streptococcaceae	.24 (.17)	.17† (.10)	0.04	.17 (.08)	0.01
Pasteurellaceae	.07 (.08)	.14† (.08)	0.0004	.10† (.08)	0.03
Neisseriaceae	.05 (.06)	.10† (.08)	0.001	.09† (.09)	0.03
Genus
Streptococcus	.24 (.16)	.17† (.10)	0.04	.17 (.08)	0.01
Haemophilus	.06 (.07)	.12† (.07)	0.0003	.09† (.07)	0.02
Neisseria	.05 (.06)	.10† (.08)	0.001	.08† (.09)	0.04
Species
S. thermophilus	.09 (.10)	.04† (.05)	0.01	.04† (.04)	0.001
H. parainfluenzae	.05 (.06)	.10† (.06)	0.002	.08† (.06)	0.03
N. flaviscens	.02 (.04)	.06† (.06)	0.002	.08† (.06)	0.02

P values adjusted for age and use of mouthwash

PDAC, pancreatic ductal adenocarcinoma; IPMN, intraductal papillary mucinous neoplasm; SD, standard deviation

^†indicates that the LDA score (log 10) >=4.0, comparing PDAC to controls or PDAC to IPMN