Fig. 3.

CRFR1 antagonism (CP 376,395; 5 mg/kg and 15 mg/kg, i.p.) given immediately before each cocaine self-administration session dose dependently reversed stress-escalated cocaine intake. Mean ± SEM total infusions of cocaine self-administration after the social defeat phase with or without prior defeat stress is portrayed. Left bars represent nonstressed control group (n=11). Right bars represent stressed group (n=12). * p < 0.05 vs. Nonstressed + saline group. # p < 0.05 vs. Stressed + saline group.