Skip to main content
. Author manuscript; available in PMC: 2018 Aug 1.
Published in final edited form as: Langmuir. 2017 Jul 19;33(30):7529–7537. doi: 10.1021/acs.langmuir.7b01132

Table 1.

Activity (IC50) and kinetics data for β-hematin formation at a lipid-water interface (37 °C, pH 4.8) in 24-well plates in the presence of antimalarial drugs.a

Drug IC50 100Y z (min−1) Kads (mM−1) k2 (M−2min−1)
Parasite β-H (μM)
CQ 14.0b
15.0 ± 2.9c
10.6 ± 1.7d 		18.8 ± 0.6 67.6 ± 0.8 0.015 ± 0.001 102.0 ± 4.7 0.12 ± 0.01
AQ 7.8b
16.0 ± 2.1c
20.4 ± 0.7d 		5.9 ± 0.3 70.1 ± 1.4 0.023 ± 0.003 566.4 ± 44.9 1.7 ± 0.4
QD 21.5b
47.0 ± 11.3c
48.0 ± 10.9d 		20.1 ± 4.1 73.6 ± 1.3 0.015 ± 0.001 32.7 ± 2.3 0.032 ± 0.005
QN 34.2b
141.0 ± 7.9c
109.8 ± 25.6d 		31.0 ± 8.3 68.1 ± 1.8 0.020 ± 0.003 61.2 ± 3.4 0.0014 ± 0.0007
a

Error calculated as standard error of the mean (SEM), following three experimental repeats, each including triplicate data points.

b

Data (nM, 3D7) reported by Hawley et al.40

c

Data (nM, D10) determined by Dr J.M. Combrinck, University of Cape Town, and communicated privately.

d

Data (nM, NF54) determined by Dr J.M. Combrinck, University of Cape Town, and communicated privately.