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. Author manuscript; available in PMC: 2018 Sep 1.
Published in final edited form as: J Mol Med (Berl). 2017 Jun 8;95(9):951–963. doi: 10.1007/s00109-017-1552-2

Figure 3.

Figure 3

KISS1 increases mitochondrial beta-oxidation. Seahorse XF24 bioanalzyer was used to measure OCR in C1861.9Vector (V) (a), C8161.9KFM59 (KFM) (b), and C8161.9KFMΔSS6(ΔSS) (c) cells treated with BSA or palmitate-BSA (Pal) with or without 40 μM etomoxir (ETO) in low glucose (0.5 mM) conditions followed by sequential injections of oligomycin (oligo), 5 μM carbonyl cyanide-4-(trifluoromethoxy)phenylhydrazone (FCCP), and 2 μM antimycin A (Ant A) and 4 μM rotenone (Rot). Endogenous (d) and exogenous (e) basal fatty acid oxidation and endogenous (f) and exogenous (g) maximal fatty acid oxidation are derived from the OCR measurements in (a-c). N ≥ 3; error bars, SEM; * P ,< 0.05