Table 2.
Univariable and Multivariable Analysis of Factors Associated with 3HP
| Factor | Discontinued No. (%) |
Univariable Analysisb RR (95% CI)a |
P Value | Multivariable Analysisc,d ARR (95% CI)a |
P Value | |
|---|---|---|---|---|---|---|
| Total n = 3288 | ||||||
| Sex | ||||||
| Male | 208 (11.8) | 0.85 (0.71–1.02) | .074 | 0.82 (0.69–0.99) | .041 | |
| Female | 213 (13.9) | Reference | ||||
| Age | 421 (12.8) | 1.01 (1.01–1.02) | <.001 | 1.01 (1.01–1.02) | <.001 | |
| Age categories (yrs.) | ||||||
| 2–17 | 9 (5.5) | 0.44 (0.23–0.85) | .014 | Not done | ||
| (18–30) | 113 (10.9) | 0.88 (0.69–1.11) | .280 | Not done | ||
| (31–44) | 119 (12.5) | Reference | Not done | |||
| (45–64) | 138 (14.7) | 1.17 (0.94–1.48) | .167 | Not done | ||
| ≥65 | 42 (21.4) | 1.72 (1.25–2.35) | ≤.001 | Not done | ||
| Race/ethnicitye | ||||||
| Hispanic | 69 (9.2) | 0.84 (0.61–1.17) | .307 | 0.89 (0.63–1.26) | .519 | |
| Non-Hispanic white | 126 (17.5) | 1.60 (1.20–2.13) | .001 | 1.22 (0.90–1.66) | .199 | |
| Non-Hispanic black | 160 (13.4) | 1.23 (0.93–1.63) | .141 | 0.88 (0.65–1.88) | .396 | |
| Asian | 59 (10.9) | Reference | Reference | |||
| Otherf | 7 (8.6) | 0.79 (0.37–1.67) | .715 | 0.72 (0.34–1.53) | .396 | |
| Treatment reasong | ||||||
| Contact | 70 (8.5) | 0.60 (0.47–0.76) | <.001 | 0.68 (0.52–0.89) | .005 | |
| Converter | 130 (16.3) | 1.39 (1.15–1.68) | ≤.001 | |||
| Corrections within past | 65 (12.6) | 0.98 (0.77–1.26) | .878 | 1.43 (1.08–1.89) | .013 | |
| Homeless within past year | 34 (18.8) | 1.51 (1.10–2.07) | .011 | 1.72 (1.25–2.39) | .001 | |
| Foreign-born | 126 (9.7) | 0.66 (0.54–0.80) | <.001 | |||
| Refugee | 19 (14.4) | 1.13 (0.74–1.73) | .574 | |||
| Health care worker | 84 (16.8) | 1.39 (1.12–1.73) | .003 | |||
| Studenth | 7 (5.4) | 0.41 (0.20–0.85) | .016 | 0.45 (0.21–0.98) | .044 | |
| Employment | 31 (15.0) | 1.16 (0.83–1.63) | .392 | |||
| Long-term care resident | 6 (12.8) | 1.00 (0.47–2.12) | .994 | |||
| Any population riskk | 219 (14.3) | 1.24 (1.04–1.48) | .018 | |||
Abbreviations: 3HP, 12 weekly doses of isoniazid and rifapentine; CI, confidence interval; RR, relative risk; ARR, adjusted relative risk; IDU, intravenous drug use.
Bolded confidence intervals indicate a statistically significant association at P≤.05
Univariable analyses test the association between the indicated factor and 3HP discontinuation.
Multivariable analyses for demographic factors and treatment reasons show the association between the indicated factor and 3HP discontinuation while controlling for all other factors listed in the model and the potential effect of the site; treats age as continuous.
All covariates were put in the model at the beginning of the backward elimination procedure; multivariable ARRs with P>0.1 are not reported.
Race/ethnicity was overall P<0.1.
Other race/ethnicity includes American Indian or Alaskan Native, Native Hawaiian or other Pacific Islander, biracial, or unknown.
Treatment reasons per local policy are dichotomous factors.
Most students were of foreign birth from high prevalence countries, or were contacts or converters; 11 patients not identified as foreign born had no treatment indication other than student status.
Any population risk was defined as being a migrant worker, health care worker, employee or resident in TB-risk setting (eg, homeless shelter or correctional facility), or resident in a long-term care facility.