Table 2. Dose escalation scheme, best responses, and dose-limiting toxicities during phase 1.

Dose Level	Decitabine	Patients (n)	Best Response	Dose-limiting toxicities
1	5 days	6	1 CR, 2 CRp, 1 RD, 2 DI	---
2	7 days	12	5 CR, 1 CRp, 1 CRi, 3 RD, 2 DI*	Respiratory failure/shock (1)
3	10 days	12	3 CR, 2 CRp, 3 MLFS, 4 RD	Respiratory failure/shock (1)

^*1 patient died before receiving MEC

Abbreviations: CR, complete remission; CRi, complete remission with incomplete blood count recovery; CRp, complete remission with incomplete platelet recovery; DI: death from indeterminate cause; MLFS, morphologic-leukemia free state; RD, resistant disease