Figure 6. Effect of varying external Ca²⁺ concentration on the endomorphin‐mediated enhancement of sustained ASIC currents.

A, ASIC3 current traces in an L‐cell exposed to pH 6.0 + 1.25 mm Ca²⁺, pH 6.0 + 1.25 mm Ca²⁺ + 10 μm E‐2 and pH 6.0 + 0 Ca²⁺ + 10 μm E‐2. B, same as A, but with E‐1. C, summary plot showing the endomorphin‐mediated ASIC3 current enhancement with varying external Ca²⁺ concentrations. Each point represents the mean (±SD, n = 5–19 cells) sustained ASIC current enhancement for E‐1 (black) and E‐2 (red). [Color figure can be viewed at wileyonlinelibrary.com]