Figure 8. Effect of E‐2 on the lactic acid‐induced reflex increase in mean arterial pressure in FP and LIG rats after ASIC1a channel block.

A and B, blood pressure (BP) responses to a lactic acid (LA, 12 mm) infusion in a rat with FP (Aa, n = 5) or LIG (Ba, n = 5) arteries. After return to baseline, naloxone (100 μg kg⁻¹) and PcTx‐1 (1 nm) were infused for 10 min and then LA + E‐2 (10 μm) were co‐infused (Ab and Bb). C, summary plots showing the mean change (±SD) in arterial pressure (MAP) following infusion of LA alone and LA + E‐2, pretreated with naloxone and PcTx‐1. ^* P = 0.006 and ^# P = 0.012 compared to FP rats using unpaired t test; ^** P = 0.036 and ^## P = 0.004 compared to LA alone, using paired t test. [Color figure can be viewed at wileyonlinelibrary.com]