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. 2017 Sep 19;595(23):7249–7260. doi: 10.1113/JP274696

Figure 9. Change in PAC with NMDA receptor blockade.

Figure 9

Compared to PAC before MK‐801 (A), PAC after MK‐801 (B) shifted to theta for phase and high‐gamma for amplitude in all genotypes except for stg/stg mice. Note that the colour map range is adjusted to appreciate changes in comodulogram structure. C, the maximum direct PAC after MK‐801 was significantly greater in +/+ than stg/stg, with intermediate responses in stg/+ and tg/tg. D, similarly, the change in direct PAC was significantly greater in +/+ than in stg/stg mice. E, frequency for phase shifted to delta for stg/stg, significantly lower than theta for phase in +/+ and tg/tg, and (F) frequency for amplitude for stg/stg was significantly lower than all other genotypes post‐MK801 (n = 6 in each group, one‐way ANOVA with Tukey's correction for multiple comparisons; *adjusted P < 0.05, **adjusted P < 0.01, **adjusted P < 0.0005).