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. 2017 Nov 30;7:16665. doi: 10.1038/s41598-017-16853-w

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Kaempferide (KF) suppresses Ti-particle induced osteolysis. (A) Micro-CT scanning showed that the loss of bone volume on KF injection group was significantly less than that of vehicle group. (B) Both HE and TRAP staining indicated an inhibitory effect of KF on osteolysis, the vehicle group showed an obvious inflammatory reaction and notably osteolysis, while the KF injection groups reveled reduced inflammation and osteolysis. (C) Bone volume against tissue volume (BV/TV), number of TRAP positive osteoclasts, number of porosity and the total porosity of each sample was measured.