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. 2017 Nov 30;7:16684. doi: 10.1038/s41598-017-16687-6

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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IRF1 is an atRA-inducible transcription factor. (a) PASTAA analysis of transcription factor affinities identified disparate transcription factors associated with atRA-inducible genes in MDA-MB-231 as compared to MDA-MB-468. (b) qPCR was used to detect expression of IRF1 in MDA-MB-231 and MDA-MB-468 cells. (c) Relative expression of IRF1 following atRA and DAC treatment in MDA-MB-231 and MDA-MB-468 cells was determined by qPCR. A two-way analysis of variance was used to compare the effect of atRA treatment to the effect of DAC treatment (*p < 0.05, **p < −0.01). (d) The expression of STAT1 was measured in MDA-MB-231 following atRA treatment and compared using a paired student’s t-test.