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. 2017 Nov 30;7:16645. doi: 10.1038/s41598-017-16622-9

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Treatment outcomes of PDAC 3D models grown as adherent monocultures (MIA-PaCa2) subjected to PDT (25 J/cm²), oxaliplatin chemotherapy (1 mM) and radiotherapy (10 Gy). (A) Brightfield and live/dead fluorescence images, obtained using a confocal microscope, as well as viability heatmaps and live area maps derived from subsequent CALYPSO analysis are given for each group. (B) Boxplot depicting the spread in normalized organoid total areas as quantified from the brightfield images depicted in panel A. (C) Boxplot depicting the spread in viability of every individual organoid within the treatment and control groups. (D) Boxplot depicting the spread in fractional live area of every individual organoid within the treatment and control groups. All boxplots depict median, 25^th and 75^th percentile, and the 90% confidence interval.