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. 2017 Nov 30;7:16650. doi: 10.1038/s41598-017-16932-y

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Generated indels in conserved region of TUNA don’t cause a significant effect on pluripotency and neural differentiation. Expression of TUNA and its downstream targets (FGF4, NANOG, SOX2) in the wildtype, compound heterozygous and homozygous edited hESCs during neural differentiation. Average standardized (according Willems et al.³⁴) CNRQ values ± 95% confidence interval (CI) are shown for 10 biological replicates of each genotype. RNA was collected of the naïve hESCs (day 0) and at day 6 of neural induction. Significant p-values are indicated with an asterisk (Wilcoxon rank sum test with BH correction, FDR = 0.05).