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. 2017 Nov 30;7:16638. doi: 10.1038/s41598-017-16726-2

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Quantified protein groups and significantly regulated proteins after treatment with BPE or Bet v 1 and LPS. (a) In total, 2474 protein groups were identified in moDCs obtained from 4 individual donors. 1505 protein groups were quantified. The Venn-diagram shows the overlap of significantly regulated protein groups (treated vs. untreated, “ut”) after the treatments. Proteins were considered to be significantly regulated if averaged and normalised ratios were greater or less than two times the standard deviation. (b) Hierarchical clustering based on Euclidian distance of 105 significantly regulated proteins after treatment of moDCs with BPE or Bet v 1 in combination with LPS. Shown are TMTsixplex™ ratios (treated vs. untreated, “ut”). Blue indicates downregulation, red highlights upregulation. The entire list of regulated proteins can be found in the supplementary excel file 2.