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. 2017 Nov 30;7:16623. doi: 10.1038/s41598-017-16811-6

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Analysis of structural N-glycan classes. Derived traits were calculated and averaged per cell line for the biological replicates from mass spectrometry analysis. Boxplots are illustrated with median and interquartile range. (A) Total high-mannose type content, (B) Total complex-type N-glycans, (C) Total hybrid type structures. Following derived traits were calculated including exclusively N-glycans of the complex type: (D) α2,6-Sialylation, (E) α2,3-Sialylation, (F) Fucosylation, (G) Multi-fucosylation defined as the presence of more than one fucose, representative for antenna-fucosylation, (H) Multi-fucosylation of α2,3-sialylated N-glycans, indicative for sialyl Lewis antigens, (I) N-glycans featuring an equal number of N-acetylhexosamines (HexNAc) compared to hexoses (Hex), (J) N-glycans featuring smaller number of Hex than HexNAc, (K) N-glycans with HexNAc = 4, indicative for di-antennary N-glycans, (L) N-glycans with HexNAc = 6, indicative for tetra-antennary N-glycans as well as LacNAc-repeats, bisecting GlcNAc, or GalNAcs additions. Traits were tested for significant differences between the samples and p-values are given in Supplemental Table S7.