Fig. 1. Elapsed time of cold and mechanical allodynia induced by paclitaxel injections.

Behavioral tests for cold and mechanical allodynia were performed before (time point zero) and after four injections of 2 mg/kg paclitaxel (days 0, 2, 4, and 6, i.p., n=10). Also, 1:1 cremophor EL and EtOH diluted in PBS was used as the vehicle (i.p., n=9). Cold (a) and mechanical (b) allodynia assessments were made by the acetone drop test and von Frey filament assay, respectively. Data is presented as mean±S.E.M.; ^***p<0.001 vs. vehicle, by Two-way ANOVA.