Fig. 2. Elapsed time of the dose-dependent effect of GBT on paclitaxel-induced cold and mechanical allodynia in mice.

Mice with paclitaxel-induced cold and mechanical allodynia were divided into four groups: PBS (PBS, n=6), GBT 3 mg/kg (GBT3, n=7), GBT 30 mg/kg (GBT30, n=7), and GBT 100 mg/kg (GBT100, n=6). PBS was used as control and both PBS and GBT were administered intraperitoneally. (a) Elapsed time and dose-dependent effect of GBT on cold allodynia. (b) Elapsed time and the dose-dependent effect of GBT on mechanical allodynia. Bl refers to baseline and represent data for behavioral assessments before the injection of paclitaxel. Data is presented as mean±S.E.M.; ^**p<0.01, ^***p<0.001 vs. PBS; by Two-way ANOVA.