Skip to main content
. 2017 Oct 30;21(6):657–666. doi: 10.4196/kjpp.2017.21.6.657

Fig. 6. Analgesic mechanism at the spinal level due to the synergistic effect of GBT and EA on paclitaxel-induced allodynia in mice.

Fig. 6

(a) Effect of naloxone, idazoxan, atropine, and PBS pretreatment on the analgesic effect of GBT and EA on paclitaxel-induced cold allodynia. (b) Effect of naloxone, idazoxan, atropine, and PBS pretreatment on the analgesic effect of GBT and EA on paclitaxel-induced mechanical allodynia. Mice with paclitaxel-induced cold and mechanical allodynia were divided into four groups: PBS (i.t., n=6), Naloxone (20 µg, i.t., n=6), Idazoxan (10 µg, i.t., n=6), and Atropine (0.1 µg , i.t., n=5). Antagonists were injected 20 min prior to GBT and EA treatment, and all behavioral assessments were made 60 min after GBT and EA treatment. Data is presented as mean±S.E.M.; **p<0.01, ***p<0.001 vs. PBS; by paired t-test.