Table 3. Univariate analysis of DFS and OS using Cox's model.
| Characteristics | DFS* | OS† | |||
|---|---|---|---|---|---|
| HR (95% CI) | p-value | HR (95% CI) | p-value | ||
| Age (lineal increment per year) | 0.99 (0.97–1.02) | 0.883 | 1.06 (1.03–1.09) | <0.001 | |
| Lymphadenectomy | |||||
| No | 1.00 | - | 1.00 | - | |
| Yes | 1.34 (0.79–2.28) | 0.282 | 0.72 (0.42–1.23) | 0.723 | |
| No. nodes removed | |||||
| No lymphadenectomy | 1.00 | - | 1.00 | - | |
| <18 nodes | 0.53 (0.24–1.14) | 0.525 | 1.13 (0.42–3.01) | 0.805 | |
| ≥18 nodes | 0.66 (0.30–1.44) | 0.298 | 1.15 (0.42–3.12) | 0.793 | |
| Adjuvant treatment | |||||
| No | 1.00 | - | 1.00 | - | |
| Yes | 1.48 (0.44–4.95) | 0.525 | 0.94 (0.31–2.85) | 0.918 | |
| Type of adjuvant treatment | |||||
| None | 1.00 | - | 1.00 | - | |
| Irradiation | 2.00 (0.85–4.70) | 0.112 | 1.02 (0.54–2.02) | 0.903 | |
| Chemotherapy | 12.31 (2.45–61.82) | 0.002 | 2.70 (0.35–21.06) | 0.344 | |
| Irradiation and chemotherapy | 2.13 (0.53–8.52) | 0.286 | - | - | |
| Histological subtype | |||||
| Endometrioid | 1.00 | - | 1.00 | - | |
| Mucinous | - | - | 0.05 (0.0–100) | 0.721 | |
| Squamous | 0.67 (0.09–4.85) | 0.670 | 0.05 (0–43.35) | 0.397 | |
| Histological grade | |||||
| G1 | 1.00 | - | 1.00 | - | |
| G2 | 1.33 (0.76–2.32) | 0.319 | 1.54 (0.86–2.76) | 0.141 | |
| G3 | 1.18 (0.45–3.13) | 0.732 | 2.84 (1.33–6.06) | 0.007 | |
| Myometrial invasion | |||||
| <50% | 1.00 | - | 1.00 | - | |
| ≥50% | 0.79 (0.40–1.57) | 0.506 | 0.66 (0.35–1.24) | 0.195 | |
| FIGO stage | |||||
| I–II | 1.00 | - | 1.00 | - | |
| IIIC | 8.64 (3.30–20.69) | <0.001 | 2.36 (0.74–7.56) | 0.201 | |
| Tumoral size (cm) | |||||
| ≤2 | 1.00 | - | 1.00 | - | |
| >2 | 2.23 (0.92–5.40) | 0.076 | 2.00 (0.93–4.31) | 0.076 | |
Multivariate analysis included all variables with p-value less than 0.10.
CI, confidence interval; DFS, disease-free survival; FIGO, International Federation of Gynecology and Obstetrics; HR, hazard ratio; OS, overall survival.
*An independent variable of recurrence in the multivariate analysis was advanced FIGO stage (HR=8.63; 95% CI=3.60–20.70; p<0.001). †Independent variables of mortality in the multivariate analysis were the age (linear increment per year HR=1.06; 95% CI=1.03–1.09; p<0.001) and the grade 3 (HR=2.52; 95% CI=1.10–5.76; p<0.029).