Table 1. Utility of POU4F3 and MAGI2 in the detection of EC and OC.
| Utility | EC (n=30) vs. Normal (n=30) | OC (n=30) vs. Normal (n=30) | |||
|---|---|---|---|---|---|
| POU4F3 | MAG12 | POU4F3 | MAG12 | ||
| M-Index* cutoff value | 21.7 | 19.6 | 16.5 | 7.7 | |
| Sensitivity (%) | 83 | 90 | 61 | 61 | |
| 95% CI | 64–94 | 73–98 | 41–79 | 41–79 | |
| Specificity (%) | 69 | 75 | 69 | 62 | |
| 95% CI | 49–85 | 55–89 | 49–85 | 42–79 | |
| AUC† | 0.8 | 0.9 | 0.6 | 0.6 | |
| 95% CI | 0.7–0.9 | 0.8–1.0 | 0.5–0.8 | 0.4–0.7 | |
AUC, area under the receiver operating characteristic curve; CI, confidence interval; EC, endometrial cancer; M-Index, methylation index; OC, ovarian cancer.
*M-Index: the value cutoff for cancer cases or normal specimens; †AUC with 95% CI of each gene was calculated for the diagnosis of cancer compare with normal.