Table 1b:

Summary of Results: Interpersonal Therapy

Indication	Results
Major Depressive Disorder
Symptoms, Treatment Response, Remission	Compared with control (usual care, clinical management, or wait list) Jakobsen et al46 Posttreatment HDRS score mean difference = −3.53 (95% CI: −4.91 to −2.16) Posttreatment BDI score mean difference = −3.09 (95% CI: −5.35 to −0.83) Patients not remitting (HDRS < 8): OR = 0.36 (95% CI: 0.24–0.55) Linde et al21(primary care patients) Posttreatment MDD scores: SMD = −0.24 (95% CI: −0.47 to −0.02) Response (≥ 50% score reduction on MDD scale): OR = 1.28 (95% CI: 0.80–2.05) Remission (symptom score below a fixed threshold): OR = 1.37 (95% CI: 0.81–2.34)
Relapse/Recurrence	Biescheuvel-Leliefeld et al29 IPT vs. usual care: Risk ratio = 0.41 (95% CI: 0.27–0.63) IPT vs. ADM: Risk ratio = 0.83 (95% CI: 0.50–1.38) Clarke et al30 IPT vs. usual care ∘ At 12 months: Risk ratio = 0.78 (95% CI: 0.65–0.95) ∘ At 24 months: Risk ratio = 0.92 (95% CI: 0.81–1.05)
Adverse Events	Not reported
Quality of Life	Not reported
Generalized Anxiety Disorder
Symptoms, Treatment Response, Remission	Not reported
Relapse/Recurrence	Not reported
Adverse Events	Not reported
Quality of Life	Not reported

Abbreviations: ADM, antidepressant medication; BDI, Beck Depression Inventory; CI, confidence interval; HDRS, Hamilton Depression Rating Scale; IPT, interpersonal therapy; MDD, major depressive disorder; OR, odds ratio; SMD, standardized mean difference.