Table 7:
Costs Used in the Economic Modela: Interventions, Usual Care, Follow-Ups, Complex Depression, and Hospitalization
| Model Parameter | Mean, $ (SE) | Distribution | Source |
|---|---|---|---|
| Costs of providing CBT, per week | |||
| Initial assessment, one-time costs, total: | 223.35 (55.84) |
Gamma | |
| GP referral | 62.75 | OHIP code K005117 | |
| Assessment by psychiatrist or psychologist | 80.30 | OHIP code K197117 | |
| CBT provided by psychiatrist, weekly | Gamma | ||
| Individual session (1 hour/week) | 160.60 (40.15) |
OHIP code K197117 | |
| Group session (2 hours/week) | 57.80 (14.45) |
OHIP code K205117 | |
| CBT provided by GP, weeklyb | Gamma | ||
| Individual session (1 hour/week) | 86.84 (21.71) |
OHIP codes K013 (first 3 sessions) and K033 (sessions 4–14)117 | |
| Group session (2 hours/week) | 63.24 (15.81) |
OHIP codes K040 (first 3 group sessions) and K041 (sessions 4–14)117 | |
| CBT provided by nonphysician, weeklyc | Gamma | Expert consultation, literature118–121: annual salary of $130,000 plus 30% benefits123,c | |
| Individual session (1 hour/week) | 101.93 (25.48) |
||
| Group session (2 hours/week) | 20.93 (5.10) |
||
| Costs of providing CBT, per week | |||
| CBT provided by nonphysician, weeklyb | Gamma | Expert consultation, literature118–121: annual salary of $130,000 plus 17% benefits122,c | |
| Individual session (1 hour/week) | 86.24 (21.56) |
||
| Group session (2 hours/week) | 17.24 (4.31) |
||
| CBT provided by nonphysician, weeklyb | Gamma | Expert consultation, literature: annual salary of $110,000 plus 30% benefits122,c | |
| Individual session (1 hour/week) | 91.73 (22.93) |
||
| Group session (2 hours/week) | 18.35 (4.59) |
||
| CBT provided by nonphysician, weeklyb | Gamma | Expert consultation, literature: annual salary of $110,000 plus 17% benefits122,c | |
| Individual session (1 hour/week) | 77.62 (19.40) |
||
| Group session (2 hours/week) | 15.52 (3.88) |
||
| Costs of pharmacotherapy,d per week | |||
| Sertraline, 50 mg/day | 6.85 | Fixed | ODB125; Kolber 2014130 |
| Sertraline, 100 mg/day | 7.44 | Fixed | ODB125; Kolber 2014130 |
| Venlafaxine, 75 mg/day | 5.93 | Fixed | ODB125; Kolber 2014130 |
| Costs of follow-up, per week | |||
| CBT only (mild MDD) | 20.85 (5.21) |
Gamma | Calculated based on OHIP codes K005 and K198117; details provided in text |
| CBT plus pharmacotherapy (moderate to severe MDD) | 33.20 (8.30) |
Gamma | Calculated based on OHIP codes K005 and K198117; details provided in text |
| Pharmacotherapy, usual care (moderate to severe MDD) | 33.20 (8.30) |
Gamma | Calculated based on OHIP codes K005 and K198117; details provided in text |
| No treatment, usual care (mild MDD) | 7.24 (1.71) |
Gamma | Calculated based on OHIP codes K005 and K198117; details provided in text |
| Costs: Complex depression | |||
| Responders, weekly | 163.78 (40.92) |
Gamma | Health Quality Ontario 2016127 |
| Nonresponders, weeklyb | 222.47 (55.61) |
Gamma | Health Quality Ontario 2016127 |
| One-time costs of hospitalization (per 10 days) | 5,422.88 (1,355.72) |
Gamma | Bereza et al,129 2012 |
| Costs: Well health state, per week | |||
| Follow-up by GP (2 visits per year) | 2.41 (0.60) |
Gamma | Calculated based on OHIP code K005117 |
Abbreviations: CBT, cognitive behavioural therapy; GP, general practitioner; ODB, Ontario Drug Benefit Program; OHIP, Ontario Health Insurance Plan Schedule of Benefits and Fees; MDD, major depressive disorder; SE, standard error.
a
Original nondiscounted costs in 2017 Canadian dollars, estimated per weekly cycle; standard error based on an assumption that the mean costs vary by ± 25%.
b
Used in probabilistic sensitivity scenario analyses.
c
Labour costs after applied salary adjustment for a full-time professional of 1,658 hours per year.
d
Costs of drugs include a dispensing fee of $10.22 and a mark-up of $1.71 for 30-day use.130