Table A4:

Assessment of the Cost-Effectiveness of CBT or Interpersonal Therapy for Major Depressive Disorder and Generalized Anxiety Disorder

Objective: To assess the cost-effectiveness of CBT and interpersonal therapy for the treatment of adults with major depressive disorder and/or generalized anxiety disorder in Ontario
Author, Year	Does the model structure adequately reflect the nature of the health condition under evaluation?	Is the time horizon sufficiently long to reflect all important differences in costs and outcomes?	Are all important and relevant health outcomes included?	Are the estimates of relative treatment effects obtained from best available sources?	Do the estimates of relative treatment effect match the estimates contained in the clinical report?	Are all important and relevant (direct) costs included in the analysis?	Are the estimates of resource use obtained from best available sources?
Wiles et al, 201668	NA	Yes	Partially	Yes	Partially	Yes	Yes
Koeser et al, 201569	Partially	No	Yes	Yes	Partially	Yes	Yes
Hollinghurst et al, 201467	NA	No	No	Yes	Partially	Yes	Yes
Kafali et al, 201466	NA	No	No	Yes	No	Yes	Yes
Prukkanone et al, 201265	Partially	Yes	No	Unclear	Partially	Yes	Unclear
Brown et al, 201157	NA	No	No	Unclear	No	Yes	Yes
Holman et al, 201164	NA	No	No	Yes	No	Yes	Yes
Sava et al, 200962	NA	No	No	Yes	No	Yes	Yes
Sado et al, 200963	Partially	No	Yes	Unclear	No	Yes	Yes
Bosmans et al, 200758	NA	No	No	Yes	No	Yes	Yes
Simon et al, 200661	Partially	No	Yes	Yes	Partially	Yes	Yes
Vos et al, 200556	Unclear	Yes	Partially	Unclear	No	Yes	Yes
Revicki et al, 200560	NA	No	No	Yes	No	Yes	Yes
Heuzenroeder et al, 200455	Unclear	No	No	Yes	No	Yes	Yes
Scott et al, 200359	NA	No	No	Unclear	No	Yes	Yes

Author, Year	Are the unit costs of resources obtained from best available resources?	Is an appropriate incremental analysis presented or can it be calculated from the reported data?	Are all important and uncertain parameters subjected to appropriate sensitivity analysis?	Is there a potential conflict of interest?	Overall assessment including applicability to the project (Minor limitations/potentially serious limitations/very serious limitations)
Wiles et al, 201668	Yes	Partially	No	Unclear	Potentially serious limitations
Koeser et al, 201569	Yes	Yes	Unclear	No	Potentially serious limitations
Hollinghurst et al, 201467	No	No	No	Unclear	Potentially serious limitations
Kafali et al, 201466	Yes	No	No	Unclear	Potentially serious limitations
Prukkanone et al, 201265	Unclear	No	No	Unclear	Potentially serious limitations
Brown et al, 201157	Yes	No	No	Unclear	Potentially serious limitations
Holman et al, 201164	Yes	No	No	Unclear	Potentially serious limitations
Sava et al, 200962	Unclear	No	No	Unclear	Very serious limitations
Sado et al, 200963	Unclear	Yes	Yes	Unclear	Potentially serious limitations
Bosmans et al, 200758	Yes	No	Unclear	Unclear	Potentially serious limitations
Simon et al, 200661	Yes	Yes	Unclear	Unclear	Potentially serious limitations
Vos et al, 200556	Yes	No	No	Unclear	Potentially serious limitations
Revicki et al, 200560	Yes	No	No	Unclear	Potentially serious limitations
Heuzenroeder et al, 200455	Yes	No	No	Unclear	Potentially serious limitations
Scott et al, 200359	Yes	No	No	Unclear	Potentially serious limitations

Abbreviation: CBT, cognitive behavioural therapy.

Note: Response options for all items were “yes,” “partially,” “no,” “unclear,” and “NA” (not applicable).