Figure 2.

Chronological relationship among extracellular amyloid aggregation, cognitive/memory symptom and protein phosphorylation changes that were identified from comprehensive phosphoproteome analysis is shown. Surprisingly, Phosphorylation of two synapse-related phosphoproteins and one splicing related protein were changed before initiation of Amyloid-beta aggregation. Protein-protein interactions among identified proteins or between kinases and substrates are indicated with lines. Reproduced from Tagawa et al., Hum Mol Genet 2015 with modifications.