Figure 3.

Strategies to narrow down the important phosphorylation sites of MARCKS in the AD pathology.²⁹⁾ We detected 30 phospho-sites in MARCKS by our mass spectroscopy analysis (right lower scheme). 16 phospho-sites were significantly changed in AD model mice, and 9 phospho-sites among them were changed at 1 month of age in 5xFAD mice. 4 in 9 phspho-sites were commonly changed in human postmortem brains (left scheme). Chronological changes of phosphorylation at the 4 phospho-sites are shown (right upper scheme).