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. 2017 Jun 16;9(3):145–150. doi: 10.1038/ijos.2017.17

Table 1. List of transcriptional regulators with predicted altered activity in response to S. mitis lysate.

Upstream regulator Molecule type Predicted activation state Activation z-score
Heat shock factor protein 1 Transcription regulator Activated 3 098
Paired box protein Pax-7 Transcription regulator Activated 3 030
Hairy/enhancer-of-split related with YRPW motif protein 1 Transcription regulator Activated 2 586
Myocyte-specific enhancer factor 2C Transcription regulator Activated 2 578
Heart- and neural crest derivatives-expressed protein 1 Transcription regulator Activated 2 449
CCAAT/enhancer-binding protein alpha Transcription regulator Activated 2 430
Estrogen receptor beta Ligand-dependent nuclear receptor Activated 2 392
Aryl hydrocarbon receptor Ligand-dependent nuclear receptor Activated 2 368
Transcription factor Sp3 Transcription regulator Activated 2 360
Transcription factor Dp-1 Transcription regulator Activated 2 330
X-box-binding protein 1 Transcription regulator Activated 2 253
CCAAT/enhancer-binding protein beta Transcription regulator Activated 2 224
Krueppel-like factor 1 Transcription regulator Activated 2 213
Early growth response protein 1 Transcription regulator Activated 2 197
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha Transcription regulator Activated 2 173
Methyl-CpG-binding domain protein 2 Transcription regulator Activated 2 128
Sterol regulatory element-binding protein 1 Transcription regulator Activated 2 095
Histone acetyltransferase KAT5 Transcription regulator Activated 2 025
WW domain-containing transcription regulator protein 1 Transcription regulator Activated 2 000
Cyclic AMP-responsive element-binding protein 3-like protein 4 Transcription regulator Activated 2 000
Hepatic leukemia factor Transcription regulator Inhibited −2 000
Transcriptional repressor protein YY1 Transcription regulator Inhibited −2 021
COP9 signalosome complex subunit 5 Transcription regulator Inhibited −2 155
Transcription regulator protein BACH1 Transcription regulator Inhibited −2 172
Nuclear factor 1 C-type Transcription regulator Inhibited −2 236
Death domain-associated protein 6 Transcription regulator Inhibited −2 392
Kelch-like ECH-associated protein 1 Transcription regulator Inhibited −2 408
Nuclear receptor ROR-alpha Ligand-dependent nuclear receptor Inhibited −2 579
Proto-oncogene c-Rel Transcription regulator Inhibited −2 868