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. 2017 Nov 30;91(24):e01283-17. doi: 10.1128/JVI.01283-17

FIG 6.

FIG 6

HAI serum antibody titers induced by COBRA VLP vaccination in Sing/86 preimmune ferrets. Ferrets were infected with Sing/86 and, 84 days later, vaccinated with VLP vaccines expressing P1 HA (red), X3 HA (blue), or CA/09 HA (green) or mock vaccinated (black). HAI titers were determined for each group ferrets against a panel of 15 H1N1 influenza viruses isolated between 1934 and 2013. The values are geometric mean titers plus the SEM (error bars). HAI titers were determined at day 14 (A) and day 84 (B) postinfection. The collected sera were tested for HAI activity against a panel of 15 H1N1 viruses isolated from 1934 to 2013. After VLP vaccination at day 84, the HAI titers were tested again at day 98 (C) and day 168 (D) postinfection. The values of each individual titer are geometric mean titers plus the SEM (error bars). The gray bar indicates the 1:40 to 1:80 HAI titer range.