TABLE 1.
Magnitude for binding to antigen panels in Fig. 1C to E, fold increase over the MVA-only group, and fold contraction and boosta
| Antigen panel | Group | Group median binding magnitude: |
Fold difference |
|||
|---|---|---|---|---|---|---|
| Wk 28 | Wk 40 | Wk 42 | Contraction (wk 28/wk 40) | Boosting (wk 42/wk 28) | ||
| gp120 breadth (8 Ags) | MVA only | 2,963 | 127 | 3,895 | 15.7 | 1.4 |
| +gp120 | 15,914 | 427 | 16,660 | 13.7 | 1.1 | |
| +MVA gp140 | 4,060 | 427 | 11,855 | 8.1 | 2.6 | |
| gp140 breadth (8 Ags) | MVA only | 5,215 | 424 | 9,223 | 8.7 | 1.5 |
| +gp120 | 16,799 | 466 | 19,009 | 17.7 | 1.2 | |
| +MVA gp140 | 7,794 | 680 | 17,323 | 8.8 | 1.8 | |
| V1V2 breadth (16 Ags) | MVA only | 5,670 | 350 | 5,026 | 13.3 | 1.0 |
| +gp120 | 12,308 | 136 | 10,477 | 42.6 | 0.9 | |
| +MVA gp140 | 10,808 | 1,347 | 12,685 | 8.0 | 1.2 | |
a
Magnitude of binding to each antigen panel was calculated as mean MFI for each breadth antigen panel as described for Fig. 1E–1G. Fold of contraction and Fold of boost were calculated as described for Fig. 2A and 2B. Values shown are group medians. Fold over MVA-only group was calculated as group median of MVA+gp120 or MVA+MVAgp140 group divided by that of the MVA-only group, for each antigen panel.