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Comb-mut containing V2 substitutions I165L and V169K is neutralized completely and efficiently by PG9 and PG16. ADA (A) and Comb-mut (B) parental pseudoviruses (black circles), as well as I165L V169K double mutants (red squares), were assayed for neutralization against PG9 (top panels) and PG16 (bottom panels). Experiments were performed in triplicate.
