FIG 6.

Neutralization of Comb-mut and CM-LK by V2 antibodies. (A) Comb-mut and CM-LK pseudotyped viruses were tested against various V2 bnAbs, as well as control antibodies PGT128 and VRC01. (B) The MPN of V2 bnAbs is shown against Comb-mut, CM-LK, and the constituent mutations of CM-LK, I165L and V169K. (C) ADA, ADA-LK, Comb-mut, and CM-LK pseudotyped viruses were tested in TZM-bl neutralization assays against gp120-gp41 interface bnAbs and the soluble form of the HIV-1 receptor, CD4. Data shown are from a representative experiment performed in triplicate, and error bars represent the standard deviations from the mean.