TABLE 2.

Substitutions I165L and V169K enhance neutralization of HIV-1 ADA and Comb-mut by PG9 and PG16

Virus	PG9			PG16
	IC50 (μg/ml)	MPN (%)	Slope	IC50 (μg/ml)	MPN (%)	Slope
ADA WT	0.272	88	0.59	0.026	94	0.56
ADA I165L	0.067	96	0.59	0.010	98	0.63
ADA V169K	0.016	99	0.49	0.006	99	0.49
ADA-LK	0.034	97	1.10	0.037	96	0.79
Comb-mut WT	0.268	92	0.89	0.099	92	0.80
Comb-mut I165L	0.158	99	0.79	0.048	98	1.26
Comb-mut V169K	0.037	100	0.83	0.017	98	1.98
CM-LK	0.030	100	1.38	0.022	100	1.33