Table 1.
Studies meeting inclusion criteria examining lipid and adipocytokine parameters in first-episode schizophrenia and related disorders
| Setting | Patients n |
DSM diagnoses | Patient age, years: mean (s.d.) |
Control group n |
Lipid parameters |
Antipsychotic status |
Patient BMI, kg/m2: mean (s.d) |
Matching | |
|---|---|---|---|---|---|---|---|---|---|
| Chen et al (2016)15 | China | 172 | Schizophrenia | 28.7 (9.9) | 31 | TC, LDL, HDL, TG | All naïve | 21.8 (3.8) | BMI, age, ethnicity, gender, smoking |
| Petrikis et al (2015)38 | Greece | 40 | Schizophrenia, schizophreniform, brief psychotic episode |
32.5 (9.8) | 40 | TC, HDL, TG | All naïve | 22.9 (3.7) | BMI, age, gender, smoking |
| Srihari et al (2013)51 | USA | 76 | Schizophrenia, schizophreniform, brief psychotic episode |
22.4 (4.8) | 156 | TC, LDL, HDL, TG | 14 days' antipsychotic use |
25.0 (4.0) | Age, gender, ethnicity |
| Enez Darcin et al (2015)39 | Turkey | 40 | Schizophrenia | 34.6 (1.1) | 70 | HDL, TG | All naïve | 24.3 (7.4) | BMI, age, smoking |
| Dasgupta et al (2010)40 | India | 30 | Schizophrenia | 32.5 (10.5) | 25 | TC, LDL, HDL, TG | All naïve | 21.0 (3.1) | BMI, age, ethnicity, diet, gender |
| Arranz et al (2004)41 | Spain | 50 | Schizophrenia | 25.2 (0.6) | 50 | Leptin | All naïve | 22.2 (2.1) | BMI, gender |
| Ryan et al (2003)18 | UK/Ireland | 26 | Schizophrenia | 33.6 (13.5) | 26 | TC, LDL, HDL, TG | All naïve | 24.5 (3.6) | BMI, age, gender, smoking, diet, exercise |
| Basoglu et al2010)42 | Turkey | 27 | Schizophrenia | 21.2 (0.8) | 22 | LDL, HDL, TG, leptin | All naïve | 22.0 (2.2) | Age, gender, smoking, BMI |
| Kirkpatrick et al (2010)43 | Spain | 87 | Schizophrenia, schizophreniform disorder, brief psychotic disorder, psychosis NOS |
27.1 (5.3) | 92 | TC, LDL, HDL, TG | <7 days' antipsychotic use |
22.3 (3.8) | Age, gender, smoking, BMI |
| Spelman et al (2007)44 | Ireland | 38 | Schizophrenia | 25.2 (5.6) | 38 | TC, LDL, HDL, TG, leptin | All naïve | 22.8 (3.1) | Age, gender, smoking ethnicity |
| Wang et al (2007)45 | Taiwan | 16 | Schizophrenia | 25.2 (4.9) | 16 | Leptin | All naïve | 22.3 (3.9) | Age, gender, BMI |
| Saddichha et al (2008)19 | India | 99 | Schizophrenia | 26.0 (5.5) | 51 | HDL, TG | All naïve | NS | Age, gender, diet, exercise |
| Sengupta et al (2008)46 | Canada | 38 | Schizophrenia spectrum disorder | 25.4 (5.6) | 36 | TC, LDL, HDL, TG | <10 days' antipsychotic use |
22.8 (3.2) | BMI, age, gender, ethnicity |
| Venkatasubramanian et al (2010)47 | India | 38 | Schizophrenia | 32.2 (7.6) | 38 | TC, TG, leptin | All naïve | 20.0 (3.1) | BMI, age, gender, socio-economic status |
| Chen et al (2016)16 | China | 60 | Schizophrenia | 28.2 (10) | 28 | TC, TG | <14 days' antipsychotic use |
21.9(3.8) | BMI, age, gender, smoking |
| Wu et al (2013)48 | China | 70 | Schizophrenia | 24.5 (7) | 44 | TC, LDL, HDL, TG | All naïve | 19.6 (2.5) | BMI, age, gender, ethnicity |
| Verma et al (2009)17 | Singapore | 160 | Schizophrenia spectrum disorder, affective psychosis, psychosis NOS, other psychotic disorders |
30.0 (6.5) | 200 | TC, LDL, HDL | <3 days' total antipsychotic use |
21.2 (3.7) | Age, gender, ethnicity |
| Misiak et al (2016)20 | Poland | 24 | Schizophrenia | 26.8 (2.9) | 146 | TC, LDL, HDL, TG | All naïve | 23.0 (2.9) | Age, gender, BMI |
| Sarandol et al (2015)50 | Turkey | 26 | At 6 months a DSM diagnosis of schizophrenia/bipolar affective disorder was made |
25.6 (7.0) | 25 | TC, LDL, HDL, TG | All naïve | 22.0 (3.3) | Age, gender, BMI, smoking |
| Kavzoglu et al (2013)49 | Turkey | 50 | Schizophrenia | 30.1 (7.5) | 50 | TC, HDL, LDL, TG | All naïve | NS | Age, gender, BMI, smoking |
BMI, body mass index; HDL, high-density lipoprotein cholesterol; LDL, low-density lipoprotein cholesterol; NOS, not otherwise specifed. TC, total cholesterol; TG, triglyceride.