Table 1. Significant association of SNPs on chromosome 1p13 in pathogen lineage-based GWAS.

						1st data set					Replication data set					Combined
rsID	Chr	Position (hg19)	Minor/major	Age	Lineage	Case count	Case MAF	Control count	Control MAF	P	case count	case MAF	control count	control MAF	P	OR (95%CI)	P
rs1418425	1	111 468 886	A/G	ALL	Non-Beijing	170	0.356	282	0.246	4.30E-04	249	0.380	489	0.278	7.05E-05	1.62 (1.35–1.93)	1.58E-07
					Beijing	93	0.290	282	0.246	0.235	174	0.339	489	0.278	0.0321	1.31 (1.06–1.62)	0.0138
rs1418425	1	111 468 886	A/G	Old	Non-Beijing	130	0.365	282	0.246	4.34E-04	182	0.404	489	0.278	9.92E-06	1.74 (1.43–2.12)	2.54E-08
					Beijing	58	0.353	282	0.246	0.0174	97	0.294	489	0.278	0.657	1.27 (0.98–1.66)	0.0743
rs1494320	1	111 422 188	G/A	Old	Non-Beijing	130	0.377	282	0.246	1.21E-04	182	0.393	489	0.282	1.01E-04	1.71 (1.40–2.08)	7.84E-08
					Beijing	58	0.371	282	0.246	5.92E-03	97	0.304	489	0.282	0.537	1.33 (1.02–1.73)	0.0319

Abbreviations: CI, confidence interval; Chr, chromosome; MAF, minor allele frequency; OR, odds ratio.